Paratesticular leiomyosarcomas are rare. We report two cases of leiomyosarcoma of the epididymis diagnosed and treated in a regional community hospital in Canada in 2009 and 2010. Both patients were males of ages 58 and 75, respectively. They presented with painless masses which, on ultrasonography, appeared to be solid masses demonstrating blood flow. Each patient underwent trans-scrotal resection of the affected epididymis. Pathological examination of trans-scrotal epididymectomy specimens confirmed the diagnosis of high-grade leiomyosarcoma. Leiomyosarcoma is an important differential diagnosis for paratesticular masses in the elderly male; the primary treatment is radical inguinal orchiectomy with high ligation of the spermatic cord.
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